| Expression pattern: |
UP |
| Associated gene: |
TRIM44, Ago2, HK2, LDHA |
| Associated microRNA: |
miR-1244 |
| Biological function: |
promotes proliferation and glycolysis and inhibits apoptosis in osteosarcoma cells; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0056285 sponges miR-1244 to increase TRIM44 expression |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Sanger Sequencing; divergent primers PCR; Actinomycin D / DRB Stability Assay; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
exosomal circ_0056285 might be a diagnostic biomarker in OS |
| Description: |
circ_0056285 is up-regulated in osteosarcoma tissues/cells and mainly localizes to the cytoplasm. It promotes osteosarcoma cell proliferation and glycolysis and inhibits apoptosis by acting as a ceRNA that sponges miR-1244 to increase TRIM44 expression; its knockdown suppresses xenograft growth and exosomal circ_0056285 shows diagnostic potential. |
| Confidence score: |
0.8735 |