| Expression pattern: |
DN |
| Associated gene: |
AGO2, DICER1 |
| Associated microRNA: |
miR-23a-3p |
| Biological function: |
inhibits cell proliferation, invasion and migration; promotes apoptosis; inhibits tumor growth and lung metastasis |
| Molecular mechanism: |
Binds AGO2 and functions as a ceRNA sponge for miR-23a-3p to upregulate DICER1 expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0007444 expression was negatively correlated with lymphatic metastasis of ovarian cancer patients |
| Description: |
hsa_circ_0007444 is down-regulated in ovarian cancer tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm, binds AGO2, sponges miR-23a-3p, and thereby increases DICER1 expression, leading to reduced proliferation/migration/invasion and enhanced apoptosis, as well as inhibited tumor growth and lung metastasis in vivo. |
| Confidence score: |
0.8443 |