circRNA basic information
circBase ID: -
Name: mmu_circ_FOXO3
Synonym: circFOXO3
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005178
MONDO name: osteoarthritis
Disease details: osteoarthritis
Disease DO ID:
 8398
Disease MeSH ID:
 D010003
Disease NCIt ID:
 C3293
Disease ICD11 ID:
 558562409
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

cartilage tissue / 关节软骨组织
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: GLUT1, HK2, PKM2, LDHA, MMP13
Associated microRNA: -
Biological function: circFOXO3 mediates the protective effect of Tougu Xiaotong Capsules in osteoarthritis chondrocytes by alleviating glycolytic metabolism disorder, reducing glycolysis-related proteins and MMP13, and delaying cartilage degeneration.
Molecular mechanism: Tougu Xiaotong Capsules upregulate circFOXO3, which suppresses glycolytic metabolism-related proteins GLUT1, HK2, PKM2, and LDHA and the matrix catabolism protein MMP13; circFOXO3 silencing attenuates these regulatory effects.
Biological pathway or process:

other pathway/process (inhibits)
Detected method:
Q
H
Validation methods:

RT-qPCR; FISH / smFISH; Transfection; Western Blot; In Vivo Animal Model
Clinical significance:

-
Description:

In mouse osteoarthritis cartilage and IL-1beta-induced chondrocytes, circFOXO3 is down-regulated. Tougu Xiaotong Capsules upregulate circFOXO3, thereby inhibiting glycolytic metabolism-related proteins and MMP13, improving extracellular matrix metabolic balance, and delaying osteoarthritis degeneration; silencing circFOXO3 weakens these effects.
Confidence score:

0.4469
Other information
Title:

[Mechanism of Tougu Xiaotong Capsules in alleviating glycolytic metabolism disorder of chondrocytes in osteoarthritis by modulating circFOXO3].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Published: 2025
PubMed ID: 41084478
Study type:

biological research
Data availability: -
Code availability: -