circRNA basic information
circBase ID: hsa_circ_0080135
Name: hsa_circ_TNS3
Synonym: -
Host Gene: TNS3
Genomic location(hg19): chr7:47341783-47409218:-
Genomic location(hg38): chr7:47302185-47369621:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: SARS-CoV-2 infection / COVID-19
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Whole Blood Samples; Lung Tissue Samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: IL12B, IL1B, IL33, CXCL10, MIP, IL13, IL7, CXCL8, IFNG, CXCL6, IL10, IL17A, CCL2, FGF2
Associated microRNA: hsa-miR-885-3p, hsa-miR-486-3p, hsa-miR-326, hsa-miR-769-3p, hsa-miR-637, hsa-miR-638, hsa-miR-654-3p, hsa-miR-665, hsa-miR-892b, hsa-miR-1231, hsa-miR-346, hsa-miR-146b-3p, hsa-miR-1203, hsa-miR-198, hsa-miR-635, hsa-miR-1200, hsa-miR-1208, hsa-miR-663b, hsa-miR-330-5p, hsa-miR-512-5p, hsa-miR-1224-3p, hsa-miR-647, hsa-miR-1290, hsa-miR-661, hsa-miR-610, hsa-miR-646, hsa-miR-671-5p, hsa-miR-558, hsa-miR-1184, hsa-miR-581, hsa-miR-361-3p, hsa-miR-924, hsa-miR-1289, hsa-miR-450b-3p, hsa-miR-3064-5p, hsa-miR-4446-3p, hsa-miR-4700-5p, hsa-miR-5787, hsa-miR-1226-3p
Biological function: Potential theranostic agent; may act as a ceRNA to sponge miRNAs and regulate cytokine storm-related mRNAs during SARS-CoV-2 infection.
Molecular mechanism: ceRNA mechanism (circRNA sponging miRNAs to regulate cytokine storm-related mRNAs).
Biological pathway or process:

ceRNA regulation (other); inflammation (other); immune regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Proposed as a potential theranostic agent for SARS-CoV-2 infection.
Description:

This study computationally prioritizes hsa_circ_0080135 as a dysregulated circRNA in SARS-CoV-2 infection and integrates it into a cytokine-storm ceRNA network. hsa_circ_0080135 is predicted to sponge miRNAs (e.g., hsa-miR-885-3p, hsa-miR-769-3p) to regulate cytokine/chemokine mRNAs (e.g., IL12B, IL1B, IL33, CXCL10, IFNG), supporting potential theranostic relevance.
Confidence score:

0.1768
Other information
Title:

Mapping CircRNA-miRNA-mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection.

Journal: PloS one
Published: 2023
PubMed ID: 37053191
Study type:

bioinformatics study
Data availability: GSE166552; PRJCA002617; GSE19137
Code availability: -