circRNA basic information
circBase ID: hsa_circ_0080942
Name: hsa_circ_PCLO
Synonym: -
Host Gene: PCLO
Genomic location(hg19): chr7:82763565-82785708:-
Genomic location(hg38): chr7:83134249-83156392:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0100096
MONDO name: COVID-19
Disease details: SARS-CoV-2 infection / COVID-19
Disease DO ID:
 0080600
Disease MeSH ID:
 D000086382
Disease NCIt ID:
 -
Disease ICD11 ID:
 1730556128
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Whole Blood Samples; Lung Tissue Samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: MIP, CXCL8, CXCL10, IL33, IL1B, IL10, IL17A, IL12B, IL13, IL7, IFNG, CXCL6, FGF14
Associated microRNA: hsa-miR-1183, hsa-miR-486-3p, hsa-miR-769-3p, hsa-miR-637, hsa-miR-1265, hsa-miR-654-3p, hsa-miR-665, hsa-miR-346, hsa-miR-1258, hsa-miR-645, hsa-miR-1303, hsa-miR-198, hsa-miR-614, hsa-miR-635, hsa-miR-331-3p, hsa-miR-557, hsa-miR-622, hsa-miR-1299, hsa-miR-296-5p, hsa-miR-609, hsa-miR-1200, hsa-miR-1208, hsa-miR-663b, hsa-miR-1224-3p, hsa-miR-513a-5p, hsa-miR-636, hsa-miR-647, hsa-miR-1290, hsa-miR-661, hsa-miR-578, hsa-miR-610, hsa-miR-671-5p, hsa-miR-518a-5p, hsa-miR-527, hsa-miR-1253, hsa-miR-1294, hsa-miR-558, hsa-miR-583, hsa-miR-1264, hsa-miR-507, hsa-miR-571, hsa-miR-924, hsa-miR-1289, hsa-miR-450b-3p, hsa-miR-135b-5p, hsa-miR-3934-3p, hsa-miR-3064-5p
Biological function: Potential theranostic agent; may act as a ceRNA to sponge miRNAs and regulate cytokine storm-related mRNAs during SARS-CoV-2 infection.
Molecular mechanism: ceRNA mechanism (circRNA sponging miRNAs to regulate cytokine storm-related mRNAs).
Biological pathway or process:

ceRNA regulation (other); inflammation (other); immune regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

Proposed as a potential theranostic agent for SARS-CoV-2 infection.
Description:

This study computationally prioritizes hsa_circ_0080942 as a dysregulated circRNA in SARS-CoV-2 infection and places it in a cytokine-storm-focused ceRNA network. hsa_circ_0080942 is predicted to sponge multiple miRNAs (e.g., hsa-miR-1183, hsa-miR-486-3p) to modulate cytokine/chemokine mRNAs (e.g., IL1B, IL33, CXCL8, CXCL10), suggesting theranostic potential.
Confidence score:

0.1768
Other information
Title:

Mapping CircRNA-miRNA-mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection.

Journal: PloS one
Published: 2023
PubMed ID: 37053191
Study type:

bioinformatics study
Data availability: GSE166552; PRJCA002617; GSE19137
Code availability: -