| Expression pattern: |
DN |
| Associated gene: |
RB1CC1 |
| Associated microRNA: |
miR-888-5p |
| Biological function: |
represses NSCLC cell progression and decreases cisplatin resistance (enhances cisplatin sensitivity) |
| Molecular mechanism: |
Circ-CUL2 sponges/negatively regulates miR-888-5p, thereby relieving miR-888-5p-mediated repression of RB1CC1; RB1CC1 knockdown reverses Circ-CUL2 effects (ceRNA axis). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); chemoresistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
Higher plasma Circ-CUL2 is associated with clinical stage and lymph node metastasis and indicates better overall survival; reduced Circ-CUL2 is linked to drug resistance. |
| Description: |
Circ-CUL2 is down-regulated in NSCLC and functions as a tumor-suppressive circRNA that reduces cisplatin resistance. Mechanistically, it negatively regulates miR-888-5p to increase RB1CC1 expression, and RB1CC1 knockdown reverses Circ-CUL2-mediated effects on NSCLC cell behaviors. |
| Confidence score: |
0.7126 |