| Expression pattern: |
UP |
| Associated gene: |
ETS1, AGO2, PI3K/AKT/mTOR signaling |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes proliferation; promotes invasion; promotes migration; promotes tumor growth and metastasis |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0008234 sponges miR-338-3p to increase ETS1 expression, affecting PI3K/AKT/mTOR signaling |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); invasion (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Significantly elevated circRNA hsa_circ_0008234 levels in colon cancer indicated that it could play a pivotal part in the diagnosis and prognosis prediction. |
| Description: |
hsa_circ_0008234 (circFOXP1, from FOXP1) is up-regulated in colon cancer tissues/cell lines and promotes proliferation, invasion, migration, tumor growth and metastasis. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA sponge for miR-338-3p to upregulate ETS1, leading to activation of PI3K/AKT/mTOR signaling. |
| Confidence score: |
0.8207 |