| Expression pattern: |
DN |
| Associated gene: |
CDK4 |
| Associated microRNA: |
hsa-miR-632, hsa-miR-574-3p, hsa-miR-362-5p, hsa-miR-429, hsa-miR-502-5p |
| Biological function: |
Overexpression of circ_0023942 inhibited human ovarian granulosa cell proliferation and suppressed CDK4 expression. |
| Molecular mechanism: |
circ_0023942 may regulate granulosa cell proliferation by suppressing CDK4; bioinformatics predicted a circ_0023942-targeted miRNA-mRNA network and MAPK signaling pathway involvement. |
| Biological pathway or process: |
proliferation (inhibits); cell cycle (inhibits); MAPK (other); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Western Blot |
| Clinical significance: |
- |
| Description: |
circ_0023942 was down-regulated in fetal-side placental tissues from maternal PCOS. Functional assays showed that circ_0023942 overexpression inhibited proliferation of human ovarian granulosa cell lines KGN and COV434, possibly through suppression of CDK4, with predicted involvement of a miRNA-mRNA network and MAPK-related pathways. |
| Confidence score: |
0.6676 |