| Expression pattern: |
UP |
| Associated gene: |
mRNAs (59 in PEM-TFI network, 120 in PEM-OEM network) |
| Associated microRNA: |
hsa-miR-608, hsa-miR-638, hsa-miR-4469, hsa-miR-4721, hsa-miR-6895-5p |
| Biological function: |
May influence oocyte quality and competence in patients with PEM. |
| Molecular mechanism: |
ceRNA mechanism with predicted miRNA sponging and downstream mRNAs via constructed circRNA-miRNA-mRNA networks. |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other); PI3K/AKT (other); p53 signaling (other); JAK/STAT (other); TGF-beta/SMAD (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May be used as a potential biomarker to help noninvasively identify whether infertility patients have concealed PEM and whether OEM affected patients have concomitant PEM lesions. |
| Description: |
hsa_circ_0004872 is significantly upregulated in cumulus cells from patients with peritoneal endometriosis-associated infertility versus OEM and TFI controls. The study constructed a predicted ceRNA network for this circRNA (binding five miRNAs and many downstream mRNAs), suggesting it may contribute to impaired oocyte quality/competence and could serve as a noninvasive biomarker for concealed PEM. |
| Confidence score: |
0.4032 |