| Expression pattern: |
DN |
| Associated gene: |
18 potential KEGG genes |
| Associated microRNA: |
hsa-miR-507, hsa-miR-375-3p, hsa-miR-576-5p, hsa-miR-942-5p |
| Biological function: |
May be involved in CHD development; proposed diagnostic biomarker for CHD. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA regulatory network; potential involvement of PI3K-Akt signaling via downstream genes targeted by miRNAs interacting with hsa_circ_0001445. |
| Biological pathway or process: |
PI3K/AKT (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low expression of hsa_circ_0001445 showed diagnostic ability to distinguish CHD patients from healthy controls (AUC 0.816; sensitivity 67.5%; specificity 76.6%); low expression was an independent risk factor/predictor for CHD. |
| Description: |
hsa_circ_0001445 is down-regulated in peripheral blood leukocytes of CHD patients and shows diagnostic utility (AUC 0.816). Bioinformatics analyses suggest it participates in a circRNA-miRNA-mRNA network potentially linked to PI3K-Akt signaling in CHD pathogenesis. |
| Confidence score: |
0.459 |