| Expression pattern: |
DN |
| Associated gene: |
RBMS1, GPX4 |
| Associated microRNA: |
miR-19b-3p |
| Biological function: |
Enhances ferroptosis and inhibits proliferation/tumour growth in HCC. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-19b-3p to elevate RBMS1, leading to decreased GPX4 and increased ferroptosis. |
| Biological pathway or process: |
ferroptosis (promotes); proliferation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; Transfection; Western Blot; EdU Staining; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circIDE expression is associated with better OS and RFS; low circIDE expression corresponds with unfavourable survival in HCC. |
| Description: |
circIDE (hsa_circ_0000251), derived from the IDE gene, is down-regulated in HCC and mainly localized in the cytoplasm. It sponges miR-19b-3p to increase RBMS1, thereby reducing GPX4 and promoting ferroptosis, which suppresses HCC cell proliferation and tumour growth; higher circIDE is associated with better survival. |
| Confidence score: |
0.8633 |