circRNA basic information
circBase ID: hsa_circ_0008717
Name: hsa_circ_ABCB10
Synonym: circ-ABCB10
Host Gene: ABCB10
Genomic location(hg19): chr1:229665945-229678118:-
Genomic location(hg38): chr1:229530198-229542371:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent tissues; tumor tissue samples
Cell lines:

A549; SPCA1; PC-9; H1299; 16HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KISS1
Associated microRNA: -
Biological function: circ-ABCB10 promotes NSCLC cell proliferation, regulates cell cycle progression, inhibits cell apoptosis, and facilitates tumorigenesis.
Molecular mechanism: circ-ABCB10 facilitates NSCLC tumorigenesis by downregulating or suppressing KISS1.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis
Clinical significance:

circ-ABCB10 may be a potential therapeutic target or candidate target for NSCLC treatment.
Description:

In this study, circ-ABCB10/hsa_circ_0008717 was up-regulated in NSCLC tissues and cell lines. Knockdown experiments in H1299 cells indicated that circ-ABCB10 promotes proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, circ-ABCB10 was reported to suppress KISS1, suggesting an oncogenic role and potential therapeutic relevance in NSCLC.
Confidence score:

0.5758
Other information
Title:

Circular RNA circ-ABCB10 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis through repressing KISS1.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32196602
Study type:

combined biological and clinical study
Data availability: -
Code availability: -