circRNA basic information
circBase ID: hsa_circ_0006220
Name: hsa_circ_TADA2A
Synonym: Circ_0006220
Host Gene: TADA2A
Genomic location(hg19): chr17:35800605-35800763:+
Genomic location(hg38): chr17:37440504-37440662:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; paired normal tissue samples; PCa tumor tissues; paired non-tumor tissue; xenograft tumors
Cell lines:

PC-3; DU 145; 22RV1; VCaP; RWPE-1; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CDCA7
Associated microRNA: miR-520f-3p
Biological function: Promotes PCa cell proliferation, growth, migration, invasion, EMT, tumor growth and metastasis; circ-0006220 knockdown inhibits these malignant behaviors.
Molecular mechanism: ceRNA mechanism: circ-0006220 acts as a sponge for miR-520f-3p and regulates CDCA7 expression, promoting malignant behaviors in PCa.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Elevated circ-0006220 expression was related to poor prognosis and lymph-node metastasis in PCa; it may be a therapeutic target.
Description:

circ-0006220/hsa_circ_0006220 is up-regulated in prostate cancer tissues and cell lines, and high expression is associated with poor survival and lymph-node metastasis. Functionally, it promotes PCa cell proliferation, migration, invasion, EMT, tumor growth and metastasis by sponging miR-520f-3p to increase CDCA7 expression.
Confidence score:

0.8069
Other information
Title:

Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)
Published: 2024
PubMed ID: 39097891
Study type:

combined biological and clinical study
Data availability: available from the corresponding author upon reasonable request
Code availability: -