| Expression pattern: |
UP |
| Associated gene: |
RAP2B, Ago2, EXT1 |
| Associated microRNA: |
miR-1184 |
| Biological function: |
Promotes bladder cancer progression by enhancing proliferation, cell cycle progression, migration, invasion, angiogenesis and EMT, while inhibiting apoptosis; its knockdown suppresses xenograft tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1184, thereby relieving miR-1184 repression of RAP2B and promoting malignant phenotypes in bladder cancer cells. |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
High circ_0008035 expression was associated with lymph node metastasis and distant metastasis in bladder cancer patients. |
| Description: |
hsa_circ_0008035 (circ_0008035), derived from EXT1, is upregulated in bladder cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, EMT) and inhibits apoptosis by sponging miR-1184 to upregulate RAP2B, and its silencing suppresses xenograft tumor growth. |
| Confidence score: |
0.8256 |