| Expression pattern: |
UP |
| Associated gene: |
PLAG1, TNS4 |
| Associated microRNA: |
miR4769-5p, miR-4796-5p |
| Biological function: |
Involved in the formation/development of 5-Fu resistance in CRC cells; potential predictive biomarker/therapeutic target for 5-Fu resistance. |
| Molecular mechanism: |
Potential ceRNA mechanism via circRNA-miRNA-mRNA regulatory axes (e.g., circ_0000236-miR4769-5p-PLAG1; hypothesized circ_0000236-miR-4796-5p-TNS4). |
| Biological pathway or process: |
ceRNA regulation (other); drug resistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Bioinformatics Analysis |
| Clinical significance: |
May serve as a biomarker to predict the occurrence of 5-Fu resistance in CRC. |
| Description: |
hsa_circ_0000236 is up-regulated in 5-Fu-resistant CRC cell lines and is implicated in promoting 5-Fu resistance via a predicted ceRNA mechanism. The study proposes axes such as circ_0000236-miR4769-5p-PLAG1 and (speculatively) circ_0000236-miR-4796-5p-TNS4, and suggests biomarker potential for predicting 5-Fu resistance. |
| Confidence score: |
0.2465 |