| Expression pattern: |
UP |
| Associated gene: |
FKBP5 |
| Associated microRNA: |
miR-766 |
| Biological function: |
promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (MH7A/RA-FLSs). |
| Molecular mechanism: |
circ_0000479 acts as a miRNA sponge for miR-766, thereby upregulating FKBP5 and promoting RA-FLS pathogenic progression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); inflammation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0000479 is up-regulated in RA-FLS (MH7A) cells and mainly localized in the cytoplasm. It promotes RA-FLS proliferation, invasion, migration and inflammatory cytokine production while inhibiting apoptosis by sponging miR-766 and thereby increasing FKBP5 expression. |
| Confidence score: |
0.7221 |