| Expression pattern: |
UP |
| Associated gene: |
KRT80, PI3K/AKT pathway |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
Promotes GC cell proliferation, invasion, migration, EMT process and tumor growth in vivo. |
| Molecular mechanism: |
circPIP5K1A functions as a ceRNA by sponging miR-671-5p, increases KRT80 expression, and activates the PI3K/AKT pathway. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circPIP5K1A may be a potential therapeutic target for the treatment of GC patients and may serve as a novel diagnostic or therapeutic target. |
| Description: |
circPIP5K1A is up-regulated in gastric cancer tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, invasion, migration, EMT and in vivo tumor growth by sponging miR-671-5p, increasing KRT80 expression and activating the PI3K/AKT pathway. The study suggests the circPIP5K1A/miR-671-5p/KRT80 axis may be a therapeutic target in GC. |
| Confidence score: |
0.7581 |