| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential less invasive plasma biomarker for auxiliary diagnosis, grading of malignant neoplasms, and prognostic prediction of gastric cancer; expression is associated with TNM stage and lymph node metastasis. |
| Molecular mechanism: |
The action mechanism of hsa_circ_0002874 in gastric cancer was not clarified in this study. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Plasma hsa_circ_0002874 showed diagnostic value for gastric cancer, correlated with tumor stage and lymph node metastasis, and had high specificity in differentiating gastric cancer from benign gastric lesions. |
| Description: |
hsa_circ_0002874 is up-regulated in plasma, gastric cancer tissues, and gastric cancer cell lines. Its plasma and tissue expression correlates with TNM stage and lymph node metastasis, supporting its potential use as a less invasive diagnostic and clinicopathological biomarker for gastric cancer. The study did not define a molecular mechanism or functional regulatory axis. |
| Confidence score: |
0.4679 |