circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_TADA2A
Synonym: circTADA2A
Host Gene: TADA2A
Genomic location(hg19): chr17:35797838-35800763:+
Genomic location(hg38): chr17:37437737-37440662:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: potential diagnostic biomarker (AUC reported)
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

ROC AUC 0.6482 for distinguishing CRC from controls (35 paired samples)
Description:

circTADA2A (hsa_circ_0043278) is elevated in CRC plasma exosomes versus healthy controls and shows modest diagnostic ability (reported AUC 0.6482) in the initial 35-pair validation set.
Confidence score:

0.4187
Other information
Title:

Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.

Journal: Translational oncology
Published: 2023
PubMed ID: 36934637
Study type:

combined biological and clinical study
Data availability: GSE126094
Code availability: -