| Expression pattern: |
UP |
| Associated gene: |
S100A16, AKT pathway, pAKT |
| Associated microRNA: |
miR-498 |
| Biological function: |
promotes CRC cell proliferation, invasion, cell cycle progression, and tumor growth; inhibits miR-498 and increases S100A16 expression |
| Molecular mechanism: |
ceRNA mechanism via miR-498 sponge to regulate S100A16 and activate the AKT pathway |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); cell cycle (promotes); AKT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; Dual Luciferase Activity Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circ-FADS2 expression was associated with advanced stages, lymphatic metastasis, and reduced overall survival (OS). |
| Description: |
circ-FADS2 is upregulated in colorectal cancer and is associated with advanced stage, lymphatic metastasis, and poor overall survival. Functionally, it promotes CRC cell proliferation, invasion, and cell-cycle progression, at least in part by sponging miR-498 to upregulate S100A16 and activate the AKT pathway. |
| Confidence score: |
0.6536 |