| Expression pattern: |
UP |
| Associated gene: |
THBS1, SLC40A1, ALDH1A1, NFAT5 |
| Associated microRNA: |
hsa-miR-1-3p, hsa-miR-27a-3p, hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-503-5p |
| Biological function: |
May promote progression of T1D (and potentially FT1D) through induction of beta-cell failure; implicated in immune response regulation. |
| Molecular mechanism: |
Predicted ceRNA mechanism: hsa_circRNA_100632 may sponge diabetes-associated miRNAs (e.g., hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-27a-3p) to modulate target genes (e.g., THBS1, SLC40A1, ALDH1A1, NFAT5). |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Diagnostic marker for FT1D; distinguishes FT1D from controls and from T1D with reported AUCs. |
| Description: |
hsa_circRNA_100632 (derived from SAMD8) is up-regulated in PBMCs of FT1D (and also T1D) patients and shows diagnostic performance for distinguishing FT1D from controls and from T1D. Mechanistically, it is predicted to act via a circRNA-miRNA-mRNA ceRNA network (e.g., sponging miR-221-3p/miR-222-3p or miR-27a-3p to affect targets such as THBS1/SLC40A1/ALDH1A1 or NFAT5), potentially linking to immune regulation in FT1D. |
| Confidence score: |
0.5047 |