| Expression pattern: |
DN |
| Associated gene: |
GAS7 |
| Associated microRNA: |
miR-196b-5p |
| Biological function: |
increases cisplatin (DDP) sensitivity, inhibits DDP resistance, restrains cell growth, and induces apoptosis in DDP-resistant ovarian cancer cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0078607 sponges miR-196b-5p to up-regulate GAS7, thereby enhancing cisplatin sensitivity |
| Biological pathway or process: |
chemoresistance (inhibits); apoptosis (promotes); proliferation (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
low circ_0078607 expression indicated a decrease in overall survival and was significantly associated with clinical stage and venous invasion |
| Description: |
circ_0078607 is down-regulated in ovarian cancer tissues and cisplatin-resistant cells and functions as a cytoplasmic ceRNA. By sponging miR-196b-5p, it up-regulates GAS7, suppresses malignant phenotypes, and increases cisplatin (DDP) sensitivity in vitro and in xenograft models; low circ_0078607 is associated with worse overall survival. |
| Confidence score: |
0.8656 |