circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1
Host Gene: SLC8A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood platelets
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: diagnostic biomarker feature in combinatorial platelet RNA signature for lung cancer and early-stage lung cancer detection
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

May improve detection of lung cancer, including early-stage, as part of a combinatorial platelet mRNA-circRNA diagnostic signature (AUC up to 0.96 for early-stage model).
Description:

circSLC8A1 is part of the selected platelet circRNA features in the combined mRNA/circRNA machine-learning models that classify lung cancer vs controls, and is retained in the early-stage lung cancer detection signature.
Confidence score:

0.1768
Other information
Title:

Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection.

Journal: International journal of molecular sciences
Published: 2023
PubMed ID: 36902312
Study type:

combined biological and clinical study
Data availability: GSE225787
Code availability: -