| Expression pattern: |
UP |
| Associated gene: |
FZD8, b-catenin, cyclin D1 |
| Associated microRNA: |
miR-99a-5p |
| Biological function: |
CircMCTP2 promotes bladder cancer cell proliferation, migration, invasion, metastasis and tumor growth, and inhibits apoptosis; its high expression is associated with metastasis and worse overall survival. |
| Molecular mechanism: |
CircMCTP2 binds and downregulates miR-99a-5p, thereby relieving miR-99a-5p-mediated suppression of FZD8 and activating the FZD8/Wnt-b-catenin signaling axis to promote bladder cancer progression. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circMCTP2 expression is associated with metastasis and worse overall survival in bladder cancer patients; circMCTP2 may serve as a biomarker and therapeutic target. |
| Description: |
CircMCTP2 is up-regulated in bladder cancer tissues and cell lines, and higher expression is linked to metastasis and poorer overall survival. Functionally, circMCTP2 promotes proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through the miR-99a-5p/FZD8/Wnt-b-catenin axis and may represent a therapeutic target or biomarker for bladder cancer. |
| Confidence score: |
0.7126 |