| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-15a-5p, miR-19a-3p, miR-135a-5p, miR-138-5p |
| Biological function: |
key player in CLL growth and progression |
| Molecular mechanism: |
miRNA sponging (miR-15a-5p; miR-19a-3p; miR-135a-5p; miR-138-5p) affecting activation pathways supporting protein acetylation, RNA polymerase II-dependent transcription, and regulation of intracellular signal transduction |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; ROC Analysis; Survival Analysis; Cohort Study |
| Clinical significance: |
Diagnostic biomarker (AUC reported) and prognostic association with 5-year OS (high level associated with worse OS). |
| Description: |
circLNPEP is increased in CLL and serves as part of a diagnostic/prognostic circRNA panel. It is predicted to function via miRNA sponging (miR-15a-5p/miR-19a-3p/miR-135a-5p/miR-138-5p) to influence intracellular signal transduction-related activation programs, and higher expression is linked to worse OS in validation cohorts. |
| Confidence score: |
0.5121 |