| Expression pattern: |
UP |
| Associated gene: |
MET, Akt |
| Associated microRNA: |
miR-34b-5p |
| Biological function: |
promotes proliferation, migration, invasion, tumorigenesis and metastasis in PDAC |
| Molecular mechanism: |
circBFAR functions as a miRNA sponge for miR-34b-5p to upregulate MET, activating downstream Akt phosphorylation and MET/PI3K/Akt signaling |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Colony Formation Assay; EdU Staining; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circBFAR overexpression correlated positively with TNM stage and was an independent prognostic factor for OS and DFS in PDAC |
| Description: |
circBFAR (hsa_circ_0009065), derived from BFAR, is upregulated in PDAC and promotes proliferation, migration/invasion, tumor growth and metastasis. It acts as a cytoplasmic ceRNA that sponges miR-34b-5p to upregulate MET, thereby activating Akt phosphorylation and MET/PI3K/Akt signaling, and high circBFAR predicts worse OS/DFS. |
| Confidence score: |
0.8837 |