| Expression pattern: |
UP |
| Associated gene: |
IGF1R |
| Associated microRNA: |
miR-326 |
| Biological function: |
circ_0000517 promotes hepatocellular carcinoma cell viability/proliferation, colony formation, migration, invasion and glycolysis; circ_0000517 knockdown suppresses these malignant phenotypes and reduces xenograft tumor growth. |
| Molecular mechanism: |
ceRNA mechanism: circ_0000517 sponges miR-326, thereby relieving miR-326-mediated repression of IGF1R. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes); metastasis (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High expression of circ_0000517 in hepatocellular carcinoma; previous study reported that upregulation of circ_0000517 indicated poor outcomes. |
| Description: |
circ_0000517 is up-regulated in hepatocellular carcinoma and promotes malignant phenotypes (proliferation/viability, migration, invasion and glycolysis). Mechanistically, it acts as a ceRNA that sponges miR-326 to increase IGF1R expression, and circ_0000517 knockdown suppresses tumor growth in a Huh7 xenograft model. |
| Confidence score: |
0.7177 |