| Expression pattern: |
UP |
| Associated gene: |
GPX4, Ago2 |
| Associated microRNA: |
miR-188-3p |
| Biological function: |
promotes osteosarcoma cell proliferation and tumor growth; enhances apoptosis resistance; inhibits ferroptosis |
| Molecular mechanism: |
ceRNA mechanism: circBLNK sponges miR-188-3p to upregulate GPX4, thereby promoting osteosarcoma progression and suppressing ferroptosis |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ferroptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
CircBLNK was significantly upregulated in OS tissues and high circBLNK expression was associated with poor prognosis in OS patients. |
| Description: |
circBLNK is upregulated in osteosarcoma tissues/cell lines and promotes tumor cell proliferation and in vivo tumor growth. It acts mainly in the cytoplasm as a ceRNA that sponges miR-188-3p to increase GPX4 expression, thereby inhibiting ferroptosis and reducing apoptosis, and high circBLNK expression correlates with poor patient survival. |
| Confidence score: |
0.8276 |