circRNA basic information
circBase ID: hsa_circ_0003759
Name: hsa_circ_LPP
Synonym: circLPP
Host Gene: LPP
Genomic location(hg19): chr3:188326948-188327632:+
Genomic location(hg38): chr3:188609160-188609844:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

malignant tissue samples; adjacent normal tissue samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic tissue biomarker (tumor vs adjacent normal) and evaluated as part of circRNA predictors for biochemical recurrence.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis
Clinical significance:

Discriminates malignant vs adjacent normal prostate tissue (AUC 0.773). Included in the reduced circRNA Cox model for BCR prediction.
Description:

circLPP is down-regulated in prostate cancer tissue by RT-qPCR and shows diagnostic discrimination between tumor and adjacent normal tissue. It was included in circRNA-only Cox models for BCR prediction, though circRNAs did not improve BCR prediction when combined with linear RNAs.
Confidence score:

0.6813
Other information
Title:

Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.

Journal: International journal of molecular sciences
Published: 2020
PubMed ID: 33105568
Study type:

combined biological and clinical study
Data availability: Supplementary Microarray Data File.xlsx
Code availability: -