| Expression pattern: |
DN |
| Associated gene: |
NOX4 |
| Associated microRNA: |
miR-9-5p |
| Biological function: |
Inhibits proliferation and migration and promotes apoptosis of hepatoma cells (tumor suppressor role). |
| Molecular mechanism: |
Acts as a molecular sponge of miR-9-5p, relieving miR-9-5p-mediated repression to upregulate NOX4. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circMTO1 is a potential diagnostic biomarker and therapeutic target for HCC. |
| Description: |
circMTO1 is down-regulated in HCC tissues/cell lines and functions as a tumor suppressor by inhibiting proliferation/migration and promoting apoptosis. Mechanistically, it sponges miR-9-5p to upregulate NOX4, forming a circMTO1/miR-9-5p/NOX4 ceRNA axis. |
| Confidence score: |
0.7357 |