circRNA basic information
circBase ID: hsa_circ_0001480
Name: hsa_circ_NTT
Synonym: circ_0001480
Host Gene: NTT
Genomic location(hg19): chr5:43615949-43645612:+
Genomic location(hg38): chr5:43615847-43645510:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: Osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Primary tumor and normal tissues; OS tissues; tumor tissues
Cell lines:

SW1353; Saos-2; HOS; SOSP-9607; hFOB 1.19
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: IBSP
Associated microRNA: miR-363-3p
Biological function: Acts as an oncogenic circRNA that promotes OS cell proliferation, invasion, and tumor growth; circ_0001480 knockdown inhibits OS progression in vitro and tumor growth in vivo.
Molecular mechanism: circ_0001480 sponges miR-363-3p and negatively modulates miR-363-3p expression, thereby regulating the downstream target IBSP in the miR-363-3p/IBSP pathway.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential target for OS treatment.
Description:

hsa_circ_0001480/circ_0001480 is upregulated in osteosarcoma tissues and cell lines and acts as an oncogenic circRNA. It promotes OS cell proliferation, invasion, and xenograft tumor growth by sponging miR-363-3p and modulating the downstream target IBSP, suggesting potential therapeutic relevance.
Confidence score:

0.7795
Other information
Title:

Hsa_circ_0001480 affects osteosarcoma progression by regulating the miR-363-3p/IBSP pathway.

Journal: Biotechnology and applied biochemistry
Published: 2024
PubMed ID: 38409882
Study type:

combined biological and clinical study
Data availability: All of the information generated or analyzed for this inquiry is contained in this article.
Code availability: -