circRNA basic information
circBase ID: hsa_circ_0046430
Name: -
Synonym: circ_0046430
Host Gene: -
Genomic location(hg19): chr17:80521229-80545148:+
Genomic location(hg38): chr17:82563353-82587272:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal tissues; colon tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SRCIN1, STRIP2, MAT1A, CYP2W1
Associated microRNA: miR-6785-5p, miR-128-1-5p, miR-4721, miR-939-3p, miR-34a-5p
Biological function: promotes the progression of colorectal cancer
Molecular mechanism: ceRNA regulatory axis (hsa_circ_0046430/miR-6785-5p/SRCIN1)
Biological pathway or process:

ceRNA regulation (promotes); proliferation (other); metastasis (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation
Clinical significance:

hsa_circ_0046430/miR-6785-5p/SRCIN1 regulatory axis impacted on CRC prognosis, suggesting novel biomarkers and therapeutic targets for CRC patients
Description:

hsa_circ_0046430 is up-regulated in colorectal cancer tissues and is proposed to act as a ceRNA within the hsa_circ_0046430/miR-6785-5p/SRCIN1 axis. The axis was supported by microarray/bioinformatics analyses and validated by qRT-PCR in paired clinical tissues, suggesting relevance to CRC progression and prognosis.
Confidence score:

0.4032
Other information
Title:

Hsa_circ_0046430 promotes the progression of colorectal cancer by targeting miR-6785-5p/SRCIN1 axis as a ceRNA.

Journal: Medicine
Published: 2023
PubMed ID: 36827049
Study type:

combined biological and clinical study
Data availability: GSE126094; GSE142837; TCGA-COAD; TCGA-READ
Code availability: -