| Expression pattern: |
UP |
| Associated gene: |
HOXB7 |
| Associated microRNA: |
miR-139-5p |
| Biological function: |
promotes CSCC cell proliferation, invasion/metastasis and EMT; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0068631 sponges miR-139-5p to upregulate HOXB7 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); RNA-seq |
| Clinical significance: |
potential target for CSCC treatment |
| Description: |
circ_0068631 is overexpressed in CSCC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, invasion/metastasis and EMT while inhibiting apoptosis, at least partly by sponging miR-139-5p to de-repress HOXB7, and it enhances tumor growth in a xenograft model. |
| Confidence score: |
0.786 |