| Expression pattern: |
UP |
| Associated gene: |
CHAF1B |
| Associated microRNA: |
miR-3619-5p |
| Biological function: |
promotes cell colony formation, migration, invasion, glycolysis and inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0026134 sponges miR-3619-5p to regulate CHAF1B expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis; Cohort Study |
| Clinical significance: |
circ_026134 expression was significantly associated with overall survival of these patients |
| Description: |
circ_0026134 is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation/colony formation, migration, invasion, glycolysis) while suppressing apoptosis. Mechanistically, it sponges miR-3619-5p to increase CHAF1B, and its knockdown inhibits xenograft tumor growth. |
| Confidence score: |
0.7524 |