circRNA basic information
circBase ID: -
Name: hsa_circ_CDKN2B-AS1
Synonym: circRNA12542
Host Gene: CDKN2B-AS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

HPV negative normal cervical epithelium; HPV16 positive normal cervical epithelium; HPV16 positive high-grade squamous intraepithelial lesion; HPV16 positive cervical squamous epithelial cell carcinoma tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AGGF1, U2AF2, MOV10, ELAVL1, ZRANB2, SF3B4, SF3B1, PUM2, FMR1, YTHDF1, DDX54, TAF15, CPSF7, CPSF6, NUDT21, CPSF4, CPSF3, AGO2, FUS, DGCR8, QKI, SRSF1, NOP58, CSTF2, GTF2F1, EIF3A, KHSRP, NOP56, ZNF622, LSM11, EFTUD2, AKAP8L, GRWD1, HNRNPK
Associated microRNA: miR-126-5p
Biological function: Potential ceRNA involved in a separate CDKN2B-AS1_0002-miR-126-5p network; identified as a crucial circRNA/network in progression from initial infection to HSIL and CSCC lesions.
Molecular mechanism: Predicted ceRNA mechanism through hsa-miR-126-5p; inverse circRNA-miRNA sponging relationship suggested.
Biological pathway or process:

ceRNA regulation (other); glycolysis (promotes); proliferation (promotes)
Detected method:
S
Validation methods:

Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential crucial circRNA/network for cervical cancer progression from initial infection to HSIL and CSCC; requires larger-cohort validation.
Description:

circRNA12542/hsa-CDKN2B-AS1_0002 was up-regulated in CSCC compared with HPV-positive and HPV-negative normal cervical epithelium. It formed a separate predicted ceRNA connection with hsa-miR-126-5p and was highlighted as a crucial circRNA/network component in cervical cancer progression.
Confidence score:

0.1768
Other information
Title:

Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.

Journal: Journal of applied genetics
Published: 2025
PubMed ID: 40531429
Study type:

bioinformatics study
Data availability: GSE147009; TCGA; CircAtlas; Transcirc; MiRWalk 3.0; CMAP2; CTDBASE
Code availability: -