circRNA basic information
circBase ID: hsa_circ_0002039
Name: hsa_circ_OSBPL9
Synonym: -
Host Gene: OSBPL9
Genomic location(hg19): chr1:52237741-52238395:+
Genomic location(hg38): chr1:51772069-51772723:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

exosomes
Cell lines:

HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with exosome-mediated transfer to recipient cells and chemoresistance transfer.
Molecular mechanism: Not experimentally defined; only general circRNA-miRNA prediction described for upregulated circRNAs.
Biological pathway or process:

ceRNA regulation (other); drug resistance (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis; Transwell Assay
Clinical significance:

-
Description:

hsa_circ_0002039 is an exosomal circRNA whose level increases in recipient HCT116-P cells after co-culture with FOLFOX-resistant HCT116-R cells, consistent with selective exosomal transfer. It is implicated in exosome-mediated chemoresistance transfer, but no specific downstream targets were experimentally validated.
Confidence score:

0.6521
Other information
Title:

Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.

Journal: Scientific reports
Published: 2019
PubMed ID: 31712601
Study type:

combined biological and clinical study
Data availability: Supplementary information is available for this paper at 10.1038/s41598-019-53063-y.
Code availability: -