| Expression pattern: |
UP |
| Associated gene: |
RRM2 |
| Associated microRNA: |
miR-758-3p |
| Biological function: |
promotes cervical cancer cell growth, proliferation, migration, invasion, EMT, metastasis and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circ_0006646 acts as a sponge for miR-758-3p to upregulate RRM2 expression, thereby promoting cervical cancer progression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis |
| Clinical significance: |
exosomal circ_0006646 might be a potential diagnostic indicator of cervical cancer; AUC value was 0.8691 |
| Description: |
circ_0006646 is up-regulated in cervical cancer cells and in plasma exosomes from cervical cancer patients. It promotes cervical cancer growth, proliferation, migration, invasion, EMT, metastasis and in vivo tumor growth by sponging miR-758-3p and increasing RRM2 expression. Exosomal circ_0006646 showed diagnostic potential for distinguishing cervical cancer patients from healthy controls. |
| Confidence score: |
0.8146 |