circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: circSLC8A1
Host Gene: SLC8A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cortex
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-7-5p
Biological function: may affect miR-7-5p target transcript levels
Molecular mechanism: circRNA-miRNA regulation affecting miR-7-5p targets
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

-
Description:

circSLC8A1 is down-regulated in AD cortex (RNA-seq and RT-qPCR). The study suggests a circSLC8A1-miR-7-5p-mRNA network in which reduced circSLC8A1 may increase miR-7-5p availability and decrease miR-7-5p target transcripts.
Confidence score:

0.4773
Other information
Title:

Identification of circRNAs linked to Alzheimer's disease and related dementias.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published: 2023
PubMed ID: 36795937
Study type:

combined biological and clinical study
Data availability: syn315774; NG00059
Code availability: -