circRNA basic information
circBase ID: hsa_circ_0008433
Name: hsa_circ_PDE4B
Synonym: circPDE4B
Host Gene: PDE4B
Genomic location(hg19): chr1:66378927-66384518:+
Genomic location(hg38): chr1:65913244-65918835:.
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004975
MONDO name: Alzheimer disease
Disease details: Alzheimer's disease / AD
Disease DO ID:
 10652
Disease MeSH ID:
 D000544
Disease NCIt ID:
 C2866
Disease ICD11 ID:
 1611724421
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cortex (Brodmann 41-42); hippocampus
Cell lines:

NPCs
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: decreased by oligomeric tau treatment in NPCs
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Clinical Sample Validation
Clinical significance:

-
Description:

circPDE4B is down-regulated in AD by RNA-seq meta-analysis and shows qPCR-validated cortical changes; it is also decreased by oligomeric tau exposure in human NPCs.
Confidence score:

0.429
Other information
Title:

Identification of circRNAs linked to Alzheimer's disease and related dementias.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published: 2023
PubMed ID: 36795937
Study type:

combined biological and clinical study
Data availability: syn315774; NG00059
Code availability: -