circRNA basic information
circBase ID: hsa_circ_0075804
Name: hsa_circ_E2F3
Synonym: -
Host Gene: E2F3
Genomic location(hg19): chr6:20402136-20402856:+
Genomic location(hg38): chr6:20401905-20402625:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal cervical tissues
Cell lines:

HeLa
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-211-5p, hsa-miR-4459, hsa-miR-3960, hsa-miR-4632, hsa-miR-4739, hsa-miR-5006-3p
Biological function: Downregulated by SCT; proposed as a main therapeutic target among the studied circRNAs in cervical cancer cells.
Molecular mechanism: Predicted miRNA sponge interactions between circE2F3 and multiple miRNAs (RegRNA prediction).
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); apoptosis (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Bioinformatics Analysis; Transfection; Annexin V/PI Flow Cytometry; Cell Cycle Assay
Clinical significance:

-
Description:

circE2F3 is downregulated by SCT in HeLa cervical cancer cells. The study predicts circE2F3-miRNA binding (miRNA sponge potential) and suggests circE2F3 as a main therapeutic target among the examined circRNAs, in the context of SCT-driven growth inhibition and apoptosis promotion.
Confidence score:

0.5416
Other information
Title:

The Pharmacological Effects of Spatholobi Caulis Tannin in Cervical Cancer and Its Precise Therapeutic Effect on Related circRNA.

Journal: Molecular therapy oncolytics
Published: 2019
PubMed ID: 31194163
Study type:

combined biological and clinical study
Data availability: TCGA; GEO: GSE63514
Code availability: -