circRNA basic information
circBase ID: -
Name: hsa_circ_TIMMDC1
Synonym: circTIMMDC1
Host Gene: TIMMDC1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019087
MONDO name: cholangiocarcinoma
Disease details: cholangiocarcinoma
Disease DO ID:
 4947
Disease MeSH ID:
 D018281
Disease NCIt ID:
 C4436
Disease ICD11 ID:
 2110597275
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human bile; bile EV samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential marker used to distinguish malignant cancers from benign biliary diseases.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
S
Validation methods:

RNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Potential marker used to distinguish malignant cancers from benign biliary diseases.
Description:

circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text.
Confidence score:

0.459
Other information
Title:

Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis.

Journal: Carcinogenesis
Published: 2023
PubMed ID: 37696683
Study type:

combined clinical and bioinformatics study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -