circRNA basic information
circBase ID: hsa_circ_0001079
Name: hsa_circ_STK39
Synonym: circ-STK39
Host Gene: STK39
Genomic location(hg19): chr2:169018296-169038600:-
Genomic location(hg38): chr2:168161786-168182090:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009831
MONDO name: malignant pancreatic neoplasm
Disease details: pancreatic cancer / PC
Disease DO ID:
 1793
Disease MeSH ID:
 -
Disease NCIt ID:
 C9005
Disease ICD11 ID:
 542147910
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PC cancer tissue; adjacent normal tissue; PC tumor tissue; lung tissues
Cell lines:

PANC-1; AsPC-1; SW1990; Capan-2; BxPC3; BxPC-3; HPDE6-C7; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRAM2
Associated microRNA: miR-140-3p
Biological function: circ-STK39 promotes pancreatic cancer cell proliferation, migration, tumor growth, pulmonary metastasis, EMT and angiogenesis; downregulation of circ-STK39 suppresses these malignant phenotypes.
Molecular mechanism: circ-STK39 acts as a miR-140-3p sponge to enhance TRAM2 expression, thereby regulating TRAM2-mediated EMT in pancreatic cancer.
Biological pathway or process:

proliferation (promotes); migration (promotes); metastasis (promotes); EMT (promotes); angiogenesis (promotes); ceRNA regulation (promotes)
Detected method:
Q
H
S
Validation methods:

RT-qPCR; RNA-seq; FISH / smFISH; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

circ-STK39 was identified as a potential biomarker and potential therapeutic target for pancreatic cancer.
Description:

circ-STK39/hsa_circ_0001079 is up-regulated in pancreatic cancer tissues and cell lines. The study shows that silencing circ-STK39 suppresses pancreatic cancer proliferation, migration, tumor growth, pulmonary metastasis and EMT by releasing miR-140-3p and reducing TRAM2-mediated EMT signaling, suggesting biomarker and therapeutic potential.
Confidence score:

0.7486
Other information
Title:

Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition.

Journal: Apoptosis : an international journal on programmed cell death
Published: 2023
PubMed ID: 37041422
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -