circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: hsa_circRNA_100833 / circFADS2
Host Gene: FADS2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006533
MONDO name: cholesteatoma of middle ear
Disease details: middle ear cholesteatoma
Disease DO ID:
 10964
Disease MeSH ID:
 D018424
Disease NCIt ID:
 C3654
Disease ICD11 ID:
 2134365487
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

middle ear cholesteatoma tissues; normal post-auricular skin samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: Associated with decreased m6A methylation in middle ear cholesteatoma (hypomethylated).
Molecular mechanism: m6A modification dysregulation; ceRNA network construction (not circRNA-specific).
Biological pathway or process:

m6A modification (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; MeRIP / MeRIP-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circRNA_100833 (circFADS2) shows significantly decreased m6A methylation in middle ear cholesteatoma and was one of five validated circRNAs used to construct a ceRNA network; the paper does not establish a cholesteatoma-specific downstream miRNA/mRNA axis for it.
Confidence score:

0.5135
Other information
Title:

N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma.

Journal: Frontiers in genetics
Published: 2024
PubMed ID: 38978876
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fgene.2024.1396720/full#supplementary-material
Code availability: -