circRNA basic information
circBase ID: hsa_circ_0003906
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; matched nontumor tissues; healthy colon tissues
Cell lines:

NCM460; SW480; SW620; HCT8; HCT116; HT29; LoVo
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May act as a suppressor in CRC; associated with poor differentiation and lymphatic metastasis; potential diagnostic biomarker.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Downregulation correlates with poor differentiation and lymphatic metastasis; ROC AUC 0.818 for distinguishing CRC tissues from healthy controls.
Description:

circRNA0003906 is significantly down-regulated in colorectal cancer tissues and most CRC cell lines. Its low expression is associated with poor differentiation and lymphatic metastasis, and it shows diagnostic potential (AUC 0.818) for distinguishing CRC tissues from healthy controls.
Confidence score:

0.6238
Other information
Title:

The expression profile and clinical significance of circRNA0003906 in colorectal cancer.

Journal: OncoTargets and therapy
Published: 2017
PubMed ID: 29123417
Study type:

combined biological and clinical study
Data availability: -
Code availability: -