| Expression pattern: |
UP |
| Associated gene: |
P2RY2, Ago2, PI3K/AKT signaling pathway, DNAJC11 |
| Associated microRNA: |
miR-761 |
| Biological function: |
Promotes ESCC cell proliferation, migration, invasion, tumor growth, and metastasis; functions as an oncogenic circRNA and potential diagnostic biomarker. |
| Molecular mechanism: |
circ_0008389 acts as a ceRNA/miRNA sponge for miR-761, stabilizes P2RY2 mRNA, inhibits mRNA degradation, and positively regulates PI3K/AKT signaling. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); mRNA stability (promotes); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; ROC Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Elevated circ_0008389 expression was correlated with tumor size, differentiation, and TNM stage; ROC curve analysis assessed diagnostic value; circ_0008389 was suggested as a potential diagnostic marker. |
| Description: |
circ_0008389 is up-regulated in ESCC tissues and patient plasma and correlates with aggressive clinicopathological features. It promotes ESCC proliferation, migration, invasion, tumor growth, and metastasis by sponging miR-761, stabilizing P2RY2 mRNA, and activating PI3K/AKT signaling. The study proposes circ_0008389 as an oncogenic driver and potential diagnostic marker for ESCC. |
| Confidence score: |
0.872 |