| Expression pattern: |
UP |
| Associated gene: |
cyclin-dependent kinase 4 (CDK4) |
| Associated microRNA: |
miR-520a-5p |
| Biological function: |
Promotes cisplatin (DDP) chemoresistance; promotes proliferation, colony formation, cell cycle progression, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Exosome-transferred hsa_circ_0014235 acts as a miRNA sponge for miR-520a-5p to relieve repression of CDK4 (ceRNA axis). |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
Proposed as a promising biomarker for NSCLC (including via serum-derived exosomes) and for NSCLC treatment. |
| Description: |
hsa_circ_0014235 is up-regulated in NSCLC tumor tissues, NSCLC cells, and NSCLC patient serum-derived exosomes. It promotes cisplatin (DDP) chemoresistance and malignant phenotypes (proliferation, migration/invasion, cell-cycle progression) while inhibiting apoptosis, partly through an exosome-associated ceRNA axis hsa_circ_0014235/miR-520a-5p/CDK4. |
| Confidence score: |
0.6833 |