| Expression pattern: |
UP |
| Associated gene: |
YY1, Ago2 |
| Associated microRNA: |
miR-1299 |
| Biological function: |
promotes proliferation, migration and angiogenesis and inhibits apoptosis in TNBC; supports xenograft tumor growth in vivo |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-1299 to regulate YY1 expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
hsa_circ_0001925 was upregulated in TNBC tissues (n=71) compared with adjacent normal tissues; expected to become a potential prognostic biomarker |
| Description: |
hsa_circ_0001925 is upregulated in TNBC tissues and cell lines and mainly localizes to the cytoplasm. It promotes TNBC malignant phenotypes (proliferation, migration, angiogenesis and tumor growth) and inhibits apoptosis by sponging miR-1299 to upregulate YY1. |
| Confidence score: |
0.8327 |