| Expression pattern: |
DN |
| Associated gene: |
HIF1AN |
| Associated microRNA: |
miR-135b-5p |
| Biological function: |
Inhibits proliferation, invasion and migration of ovarian cancer cells; acts as a tumor suppressor. |
| Molecular mechanism: |
Acts as a sponge (ceRNA) of miR-135b-5p to increase HIF1AN expression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Western Blot; IF (Immunofluorescence); MTT; CCK8; Transwell Assay; Wound Healing Assay |
| Clinical significance: |
Potential diagnostic and treatment target for ovarian cancer. |
| Description: |
CDR1as is down-regulated in ovarian cancer tissues/cells and suppresses ovarian cancer cell proliferation, invasion and migration. Mechanistically, it sponges miR-135b-5p to relieve repression of HIF1AN, contributing to a tumor-inhibitory effect. |
| Confidence score: |
0.5758 |