| Expression pattern: |
UP |
| Associated gene: |
CXCL12, Ago2 |
| Associated microRNA: |
miR-296-5p |
| Biological function: |
Promotes BC cell viability, clonogenic potential, migration, invasion, tumor growth, immune escape, and inhibits CTL infiltration. |
| Molecular mechanism: |
circ_002172 acts as a miR-296-5p sponge to upregulate CXCL12 expression, thereby inhibiting CTL infiltration and promoting immune escape and breast cancer progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); immune regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
The circ_002172/miR-296-5p/CXCL12 axis may have potential application value for BC diagnosis and treatment. |
| Description: |
circ_002172 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes BC cell proliferation/viability, colony formation, migration, invasion, and tumor growth by sponging miR-296-5p to increase CXCL12 expression. Through the circ_002172/miR-296-5p/CXCL12 axis, it reduces CTL infiltration and promotes immune escape, suggesting potential diagnostic or therapeutic relevance. |
| Confidence score: |
0.8254 |