| Expression pattern: |
UP |
| Associated gene: |
ENAH |
| Associated microRNA: |
miR-874-3p |
| Biological function: |
Promotes proliferation, migration, invasion and glycolysis; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-874-3p to upregulate ENAH (ceRNA-like regulation). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Might provide novel therapeutic targets for esophageal cancer intervention. |
| Description: |
circ_0003340 is upregulated in esophageal cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, glycolysis and tumor growth) and suppresses apoptosis by sponging miR-874-3p to increase ENAH expression. |
| Confidence score: |
0.7855 |