| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-182, miR-433 |
| Biological function: |
circ_0079593 facilitates glioma cell growth, migration and invasion, and inhibits apoptosis; circ_0079593 knockdown suppresses proliferation and metastatic properties and increases apoptosis. |
| Molecular mechanism: |
circ_0079593 acts as a competing endogenous RNA by sponging and negatively regulating miR-182 and miR-433; rescue assays showed its biological functions depend on inhibition of miR-182 and miR-433. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ_0079593 expression was associated with larger tumor size, higher WHO grade, worse survival, and was an independent prognostic indicator for glioma patients. |
| Description: |
circ_0079593 is up-regulated in glioma tissues and cell lines and high expression predicts worse survival, larger tumor size, and higher WHO grade. Functionally, it promotes glioma cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0079593 acts as an oncogenic miRNA sponge that negatively regulates miR-182 and miR-433. |
| Confidence score: |
0.7396 |