circRNA basic information
circBase ID: hsa_circ_0011298
Name: hsa_circ_TINAGL1
Synonym: circ_0011298
Host Gene: TINAGL1
Genomic location(hg19): chr1:32050751-32051086:+
Genomic location(hg38): chr1:31585150-31585485:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; corresponding normal tissues; tumor tissues
Cell lines:

A549; H1299; A549/Taxol; H1299/Taxol
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CRABP2, Ago2
Associated microRNA: miR-486-3p
Biological function: promotes Taxol resistance, proliferation, migration, invasion, and glycolysis; inhibits apoptosis and cell cycle arrest in Taxol-resistant NSCLC
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-486-3p to upregulate CRABP2, thereby enhancing Taxol resistance
Biological pathway or process:

chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); glycolysis (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; EdU Staining; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

Circ_0011298 was higher in Taxol-resistant NSCLC tissues than that in Taxol-sensitive NSCLC tissues
Description:

In Taxol-resistant NSCLC, circ_0011298 is upregulated and mainly localized in the cytoplasm. It promotes Taxol resistance by acting as a sponge for miR-486-3p, thereby increasing CRABP2 expression and enhancing proliferation, migration/invasion, and glycolysis while reducing apoptosis and cell-cycle arrest.
Confidence score:

0.8443
Other information
Title:

Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis.

Journal: Journal of clinical laboratory analysis
Published: 2022
PubMed ID: 35396749
Study type:

combined biological and clinical study
Data availability: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -