| Expression pattern: |
DN |
| Associated gene: |
TIMP3, AGO2, MMP9, E-cadherin, Vimentin |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
Suppresses HCC cell proliferation, migration and invasion; arrests cell cycle in G2 phase; promotes apoptosis; inhibits tumor growth in vivo; inhibits angiogenesis |
| Molecular mechanism: |
Acts as a miR-590-5p sponge to regulate TIMP3, affecting downstream metastasis-related proteins (MMP9, E-cadherin, Vimentin). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); apoptosis (promotes); angiogenesis (inhibits); NF-kappaB (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; RNA-seq |
| Clinical significance: |
Higher circDCUN1D4 expression levels exhibited better survival rates compared to patients with lower expression levels; significantly associated with TNM staging. |
| Description: |
circDCUN1D4 is down-regulated in HCC and acts as a tumor suppressor by inhibiting proliferation, migration/invasion and promoting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-590-5p to regulate TIMP3, affecting metastasis-related proteins (e.g., MMP9, E-cadherin, Vimentin). Higher circDCUN1D4 expression is associated with better patient survival and circDCUN1D4 delivery suppresses xenograft growth in mice. |
| Confidence score: |
0.8847 |