| Expression pattern: |
UP |
| Associated gene: |
AKT2, Ago2 |
| Associated microRNA: |
miR-211-5p, miR-377-3p |
| Biological function: |
promotes proliferation; promotes invasion; promotes tumor sphere formation; promotes angiogenesis; promotes tumorigenesis |
| Molecular mechanism: |
ceRNA mechanism: circ_0000118 sponges miR-211-5p and miR-377-3p to release repression of AKT2 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
high level of circ_0000118 was connected to a poorer prognosis in CC patients |
| Description: |
circ_0000118 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes malignant behaviors (proliferation, invasion, sphere formation, angiogenesis) and tumor growth by sponging miR-211-5p and miR-377-3p to maintain AKT2 expression. |
| Confidence score: |
0.8677 |