| Expression pattern: |
DN |
| Associated gene: |
FBXW7 |
| Associated microRNA: |
miR-25-3p |
| Biological function: |
Inhibits ccRCC cell migration, invasion, EMT, and pulmonary metastasis; suppresses tumor growth in xenograft model. |
| Molecular mechanism: |
Acts as a ceRNA (miRNA sponge) for miR-25-3p to increase FBXW7 expression, thereby inhibiting EMT and metastasis. |
| Biological pathway or process: |
EMT (inhibits); metastasis (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Microarray; RNA-seq; RT-qPCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Low circPSD3 expression was associated with tumor metastasis in patients with ccRCC; circPSD3 showed good performance for predicting metastasis (AUC 0.824). |
| Description: |
circPSD3 (hsa_circ_0002111), derived from PSD3, is down-regulated in ccRCC tissues and cell lines and is associated with metastasis. Functionally, circPSD3 suppresses migration/invasion, EMT, and lung metastasis by sponging miR-25-3p to upregulate FBXW7, forming the circPSD3/miR-25-3p/FBXW7-EMT axis. |
| Confidence score: |
0.8693 |