| Expression pattern: |
UP |
| Associated gene: |
CBL |
| Associated microRNA: |
miR-495-3p |
| Biological function: |
facilitates RCC cell proliferation and metastasis and inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circTLK1 acts as a ceRNA by sponging miR-495-3p to upregulate CBL |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
circTLK1 expression was associated with tumor size, lymph node metastasis, and TNM stage |
| Description: |
circTLK1 (hsa_circ_0004442), derived from TLK1, is up-regulated in RCC tissues and cell lines. It promotes RCC proliferation, migration/invasion, EMT and tumor growth while inhibiting apoptosis by sponging miR-495-3p to upregulate CBL. |
| Confidence score: |
0.6973 |